GLP-1s, Muscle, and the Volume That Disappears With the Weight

I sat down with Dr. Kristy Hamilton — a board-certified plastic surgeon, a dear friend, and the person I consider the resident plastic surgeon in this ecosystem — and by the end of our conversation I kept returning to a single tension. GLP-1 medications have done something extraordinary. They’ve also created a problem almost nobody is discussing with any precision.

Those two facts sound like they’re in conflict. They aren’t. They’re the same story told from both ends. When you strip weight off the body without a plan to defend the tissue underneath it, you don’t just lose fat. You lose structure. And structure — muscle first, then the architecture that sits on top of it — is the thing that carries you through the back half of your life.

The Dark Side Nobody Put in the Brochure

Let me be clear about what GLP-1s have done well, because it’s real. Dr. Hamilton described them as having revolutionized her field. Patients who were never surgical candidates — people carrying too much weight to safely operate on — are now walking in at a body composition that makes real reconstruction possible. That is a legitimate win.

But there is a cost, and it shows up in the places we don’t want to lose volume: the face, the buttock, the breast. And underneath all of it, skeletal muscle.

This is where the conversation stopped being about aesthetics for me and started being about physiology. When weight comes off this fast, it doesn’t come off as fat alone. A meaningful fraction of it is lean mass — the organ of longevity itself. Dr. Hamilton is now seeing the downstream evidence on the operating table: patients who have lost so much fat that the supportive tissue collapses, the skin no longer fits the frame, and even a well-built glute can begin to sag because the scaffolding that held it up is gone.

Her patients call it the “diaper butt,” which is not elegant but is accurate. Facial hollowing that reads as a decade of aging compressed into a year. Loose skin over a body that is, by every training metric, in excellent shape. This is the under-muscled phenotype made visible.

Replacing What the Weight Loss Took

A guiding principle in plastic surgery, Dr. Hamilton explained, is to replace like with like. If the face has lost fat, you would ideally rebuild it with fat. The problem is that the GLP-1 patient often has no fat left to give.

So the field has engineered a workaround. There are now processed donor-fat products — Allo Clay, Lipodermal — irradiated and washed of DNA so the body won’t reject them, in the same way it won’t reject a properly matched graft. Social media has nicknamed the result the “zombie BBL,” which is an unfortunate name for what is, mechanically, a soft-tissue graft placed where a patient’s own fat reservoir used to be.

Dr. Hamilton was measured here, and I appreciated it. These are relatively new products, the long-term studies do not yet exist, and the companies know it. She uses them on-label, in the subcutaneous plane, and she still prefers a patient’s own fat when there is any to harvest. That is the difference between an operator chasing a trend and a physician exercising rigorous judgment.

She has also designed her own answer to the specific laxity these medications create — the Miami Thong Lift. It targets the lower inner quadrant of the buttock in patients who do not need a full body lift, redistributing tissue higher to restore a lifted, athletic shape rather than an exaggerated one. This is not about adding volume for its own sake. It is a structural correction for a structural problem — and notably, it is a problem she almost never saw before these drugs arrived.

The Case for Sparing the Muscle

Here is the part of the conversation most relevant to anyone who trains.

Dr. Hamilton is one of roughly 32 surgeons in the United States trained in a pec muscle-sparing breast augmentation called Preserve. For decades, the standard in this country has been to place the implant behind the pectoralis muscle — which means cutting into one of the most important shoulder stabilizers on the front of the body. If you have had that operation, you are, technically, not supposed to do a push-up or a bench press again.

Sit with that. We have been asking women to choose between an aesthetic result and their ability to train their chest for the rest of their lives.

The pec-sparing approach places the implant in front of the muscle, through a one-inch incision, working between the breast’s own ligaments and preserving the nerves and blood supply. Recovery to full exercise is about a week, versus six weeks or longer when the muscle is cut. Outside the United States, roughly 80% of augmentations are already performed in front of the muscle; here that ratio has been flipped, largely because of past limits on implant technology and tools rather than physiology.

I have no personal stake in whether anyone gets breast surgery. I have an enormous stake in the principle underneath it: the pectoralis is functional tissue. When you cut muscle, you change the way a body moves — sometimes subtly, sometimes for good. An approach that defends that muscle is, to me, the entire point.

What This Isn’t

I want to be precise here, because there is a version of this conversation that goes off the rails, and both Dr. Hamilton and I were deliberate about not letting it.

Breast implant illness is real to the women who live it, and neither of us has any interest in diminishing anyone’s experience. It is also a subject that has been overrun by predatory actors. So here is what the research indicates. A multi-part study conducted with the NIH compared women who never had implants, women having implants removed for symptoms, and women having implants exchanged. Investigators examined tissue for heavy metals, toxins, and bacteria. Across those categories, research did not find a statistically significant difference between the groups. What it did find was an association with higher baseline anxiety in the group reporting symptoms — which is not the same as saying the symptoms are not real, and that distinction matters.

The encouraging finding: when the implants are removed, symptoms resolve in the large majority of cases within about six weeks — and, importantly, without cutting out the surrounding capsule or performing the aggressive, deforming procedures some clinics push.

That is where the predatory behavior lives. Nobody needs a $30,000 detox program. Nobody needs what remains of their breast excised to feel better. Between us, we have seen patients talked into disfiguring surgery for implants that were not physically bothering them, whose symptoms did not resolve, and who were left more anxious and now deformed. Be skeptical of anyone selling a dramatic, expensive intervention for a problem a far simpler one would address.

The same pattern shows up in the aesthetic ideal itself. The exaggerated look is receding. What patients are asking for now is lean, athletic, proportionate — the “clean girl” skin, the natural frame. That shift is not an accident. It tracks a broader move toward valuing a body that works over a body that merely performs for a camera.

The Skin You Cannot Train Away

This is the real limitation, and I will speak from personal experience. After two kids and years of training, I looked at a video one day and noticed loose skin on my stomach, my back, and my knees that I had not clocked before. So I did what anyone does, I asked around, and I got a parade of expensive answers: microneedling, topical creams, a $10,000 package at a med spa. Most of it would not have touched the actual problem.

Here is the framework Dr. Hamilton laid out, and it is worth committing to memory. Skin treatments treat skin — texture, tone, pigment, fine lines. They do not reset structure. Energy-based devices — radiofrequency, ultrasound, laser — all work by heating tissue to a temperature that triggers collagen induction, a controlled injury that recruits the body’s own repair machinery. And surgery is the only thing that removes meaningful excess skin.

If you have true overhang when you stand up straight, no device will fix it, and anyone selling you radiofrequency for that outcome is taking your money. But for the patient in between — real laxity, no excess to excise — there is a viable option. In my case we used Quantum RF, a radiofrequency device applied beneath the skin through tiny incisions, heating the fibroseptal network that supports the fat so it cinches back down. A reasonable expectation is a 20–30% improvement per treatment, typically over two sessions. It is not a treatment that “wears off.” Aging simply continues along its own continuum, which is a luxury, not a grievance.

One more development is worth knowing, because it changes the calculus on tolerating these procedures at all. Dr. Hamilton has been using Journavx (suzetrigine), the first new class of pain medication in over two decades. It is a non-opioid that acts on sodium channels in the peripheral nervous system — no euphoria, no change in consciousness, no addiction profile. Approved for acute pain, it is allowing physicians to deliver stronger, more effective treatments without loading patients with narcotics. That matters well beyond aesthetics.

And none of this replaces the daily work. Retinoids, disciplined sun protection, and consistent collagen-building treatments — what Dr. Hamilton calls collagen banking — are the durable, unglamorous baseline. You cannot buy your way past that. You maintain it.

Where This Leaves Us

The throughline across all of it — the volume loss, the sagging structure, the loose skin, the surgical choices — comes back to the same principle I build everything on. Muscle is the organ of longevity. When you pursue weight loss without defending lean mass, the body you are left with reflects that omission, and no procedure fully compensates for it.

The most striking thing Dr. Hamilton said all day: her fittest patients heal beautifully and move through recovery with ease — and they are also the ones most bothered by loose skin, precisely because they are lean enough to see everything. You cannot exercise away excess skin; in some cases training reveals more of it. Aesthetic medicine, at its best, is the last step on a journey the patient has already done the hard work to earn. It is not a shortcut, and it was never meant to be one.

That is the accountability I would ask you to hold. Do the work that builds the tissue. Understand the trade-offs before you sit in anyone’s consultation room. And when someone promises you a dramatic result with no effort and a large invoice, walk out.

A few things worth taking with you:

  • If you are on a GLP-1, defend your muscle deliberately. Anchor your meals with adequate high-quality protein and train with resistance. Rapid weight loss without a lean-mass strategy accelerates the exact volume and skin problems described here.
  • Ask how an operation treats muscle before you consent to it. A muscle-sparing approach can be the difference between a one-week recovery and a permanent restriction on how you train.
  • Separate skin quality from skin structure. Topicals and energy devices improve quality; they do not remove meaningful excess. Match the intervention to the actual problem.
  • On breast implant illness, respect the experience and scrutinize the sales pitch. Removing the implants resolves symptoms in most cases without radical surgery. You do not need a five-figure “detox.”
  • Build collagen as a standing habit, not a one-time fix. Retinoids, sun protection, and consistent treatments are the baseline. Aging continues; the work continues with it.

My thanks to Dr. Kristy Hamilton for a conversation that was direct, evidence-based, and willing to name the trade-offs instead of flattening them into a slogan. That is the kind of dialogue this space exists for.

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Evy Poumpouras

Evy Poumpouras is a multi-platform journalist, host, and exclusive contributor to NBC across all their news platforms, covering national security, law enforcement, and crime. Evy’s book, BECOMING BULLETPROOF, was released by Simon & Schuster in 2020 and covers a wide range of topics, including personal protection, behavioral analysis, situational awareness, and how to live life fearlessly. Outside of her role as a journalist, Evy is a TEDx speaker whose expertise is sought worldwide.

 Dr. Susan Peirce Thompson

Susan Peirce Thompson, Ph.D. is a faculty member in brain and cognitive sciences at the University of Rochester, a multiple New York Times bestselling author, and a keynote speaker on how the brain supports human flourishing. In 2014, she founded Bright Line Eating, a worldwide movement dedicated to helping people achieve permanent weight loss maintenance. Over 115,000 people from more than 100 countries have taken her courses and you can find her online at BrightLineEating.com or SusanPeirceThompson.com.

Dr. Mark Hyman

Mark Hyman, MD, has devoted his life to helping others discover optimal health and address the root causes of chronic disease through the power of Functional Medicine. Dr. Hyman is a practicing family physician and an internationally recognized leader, speaker, educator, and advocate in the field of Functional Medicine. He is a co-founder and the Chief Medical Officer of Function Health, founder and Director of The UltraWellness Center, founder of Cleveland Clinic Center for Functional Medicine and Board Member for The Institute of Functional Medicine.

He is the founder and chairman of the Food Fix Campaign, dedicated to transforming our food and agriculture system through policy. Dr. Hyman is also the host of one of the leading health podcasts, The Dr. Hyman Show, with 300+ million downloads and a fifteen-time New York Times best-selling author. He is a regular medical contributor to several television shows and networks, including CBS This Morning, Today, Good Morning America, The View, Fox and CNN.


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Jeff Cavalier is a fitness guru, social media star, personal trainer, and former head physical therapist of the New York Mets (professional baseball team). Jeff earned a Bachelor of Science in Physioneurobiology/Premedicine and a Master's degree in Physical Therapy from the University of Connecticut. He is a Certified Strength and Conditioning Specialist (CSCS) by the National Strength and Conditioning Association (NSCA). Jeff served as both the Head Physical Therapist and Assistant Strength Coach for the New York Mets during the National League East Championship 2006, 2007, and 2008 seasons. During this time, he coached some of the game’s most accomplished players, including future Hall of Fame pitchers Tom Glavine and Pedro Martinez, and perennial all-stars Carlos Delgado, Carlos Beltran, David Wright, Jose Reyes, and Billy Wagner, to name just a few. In addition to physiotherapy and training, Jeff is an author and lecturer speaking on topics such as baseball injury prevention, sport-specific conditioning, sports training, and injury rehabilitation and prevention. Jeff founded ATHLEAN-X Training System to share methods and techniques used by some of the greatest athletes to forge explosive and strong physiques. This is a science-based training system allowing anyone to get the same results as professional athletes.

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Jeff Cavalier

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Originally studying biology to become a doctor, Heidi discovered her real calling after experiencing her own fitness and mindset transformation. What started with sharing simple tips online grew into two globally recognized brands: Buffbunny Collection, a leading women’s activewear company, and Grounds, a fitness app built to give women the tools, education, and community they deserve.

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Shade Zahrai

Dr. Shadé Zahrai is a behavioral researcher, award-winning peak performance educator, and leading authority on confidence and self-doubt. A former corporate lawyer with an MBA and background in psychology, she has designed and delivered transformative programs for Fortune 500 giants including Google, Microsoft, LVMH, JP Morgan, and McKinsey. Named one of LinkedIn’s Top Voices for career development, Shadé has taught over 7 million learners on LinkedIn Learning. Her TEDx talks and viral videos have amassed more than 300 million views, and her work has been featured in The New York Times, Adweek, CNBC, and Yahoo Finance.

Jocko Willink

Jocko Willink is a decorated retired U.S. Navy SEAL officer, co-author of the #1 New York Times bestsellers Extreme Ownership: How U.S. Navy SEALs Lead and Win and The Dichotomy of Leadership, and host of the top-rated Jocko Podcast. He is the co-founder and Chief Executive Officer of Echelon Front, a premier leadership consulting firm; the founder of Jocko Fuel, a performance nutrition and lifestyle company committed to clean, uncompromising quality; and the co-founder of Origin USA, a Made in America company producing apparel, boots, and gear. Across his ventures, Jocko serves as an instructor, speaker, executive coach, and strategic advisor.

Jocko spent 20 years in the SEAL Teams, serving in both enlisted and officer roles before rising to command SEAL Team Three’s Task Unit Bruiser during the Battle of Ramadi. There, he led combat operations that supported the U.S. Army’s 1st Armored Division “Ready First” Brigade in bringing stability to one of the most violent regions in Iraq. Task Unit Bruiser became the most highly decorated Special Operations unit of the Iraq War.

Following his combat deployments, Jocko served as Officer-in-Charge of training for all West Coast SEAL Teams, where he spearheaded the development of leadership training and personally mentored the next generation of SEAL leaders. His career awards include the Silver Star, the Bronze Star, and numerous other personal and unit commendations.

Since retiring from the Navy in 2010, Jocko has dedicated himself to sharing the leadership principles forged in combat to help leaders in business, government, education, and non-profits win on their own battlefields. He built Jocko Fuel after discovering harmful levels of heavy metals in a supplement he and his family once used daily, committing to a standard of only what you need—none of what you don’t. Through Origin USA, he champions American manufacturing, producing world-class apparel and gear entirely in the U.S.

Michelle Shapiro

Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem Ipsum.

Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem Ipsum.

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Arthur Brooks

Arthur Brooks is a professor at the Harvard Kennedy School and the Harvard Business School, where he teaches courses on leadership and happiness. He is also the host of the weekly podcast “Office Hours with Arthur Brooks,” and a columnist at The Atlantic, where he writes the popular weekly “How to Build a Life” column.

Brooks is the author of 15 books, including the #1 New York Times bestsellers, Build the Life You Want, co-authored with Oprah Winfrey, and From Strength to Strength: Finding Success, Happiness, and Deep Purpose in the Second Half of Life. His next book, The Meaning of Your Life: Finding Purpose in an Age of Emptiness, will be released on March 31, 2026.

Brooks is one of the world’s leading experts on the science of human happiness, appearing in the media and traveling the world to teach people in private companies, universities, public agencies, and faith communities how they can live happier lives and bring greater well-being to others.

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